Author

Linley R. Pierce

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Robert C. OrchardiD· 5 shared Mikayla C. Olson· 3 shared Mridula Annaswamy SrinivasiD· 2 shared Brittany M. StewartiD· 1 shared Chengyuan JiiD· 1 shared Gail L. SturdevantiD· 1 shared Lawrence A. SchrieferiD· 1 shared Meagan E. SullenderiD· 1 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersMicrobiology

Robert C. OrchardORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Plscr1 inhibits murine norovirus entry

Nina S. Baggett, Linley R. Pierce, Robert C. Orchard

This study identifies Plscr1 as a restriction factor for murine norovirus, showing it inhibits infection through a post-attachment entry step.

bioRxiv · Sep 19, 2026 · PreprintMicrobiology

Trim47 inhibits murine norovirus replication in a strain-dependent manner

Stacey L. Crockett, Linley R. Pierce, Rachel Rodgers, Meagan E. Sullender, Lawrence A. Schriefer, Mridula Annaswamy Srinivas, Sanghyun Lee, Megan T. Baldridge, Robert C. Orchard

This study identifies Trim47 as a host restriction factor that inhibits murine norovirus strain CR6 but not strain CW3, revealing strain-specific antiviral mechanisms.

Journal of Virology · Nov 18, 2025Peer-reviewedMicrobiology

Trim7 does not have a role in the restriction of murine norovirus infection in vivo

Mridula Annaswamy Srinivas, Linley R. Pierce, Mikayla C. Olson, Shelly J. Roberston, Gail L. Sturdevant, Sonja M. Best, Robert C. Orchard

This study shows Trim7 does not restrict murine norovirus infection in vivo, despite its antiviral activity in cell culture.

Journal of Virology · Jun 4, 2025Peer-reviewedMicrobiology

Development of a replication competent murine norovirus reporter system

Mikayla C. Olson, Linley R. Pierce, Robert C. Orchard

This paper develops a luciferase-based reporter system for murine norovirus to study replication and screen antiviral compounds.

PLoS Pathogens · May 22, 2025Peer-reviewedMicrobiology

Membrane asymmetry facilitates murine norovirus entry and persistent enteric infection

Brittany M. Stewart, Linley R. Pierce, Mikayla C. Olson, Chengyuan Ji, Robert C. Orchard

This study shows that lipid asymmetry, mediated by TMEM30a, is essential for murine norovirus entry and persistent infection.

PLoS Biology · Apr 17, 2025Peer-reviewedMicrobiology