Robert C. Orchard

This study identifies Plscr1 as a restriction factor for murine norovirus, showing it inhibits infection through a post-attachment entry step.

This study identifies a single amino acid mutation in norovirus NS4 that rescues replication defects of a specialist virus, enabling it to spread more efficiently in vitro.

This study identifies Trim47 as a host restriction factor that inhibits murine norovirus strain CR6 but not strain CW3, revealing strain-specific antiviral mechanisms.

This study shows Trim7 does not restrict murine norovirus infection in vivo, despite its antiviral activity in cell culture.

This paper develops a luciferase-based reporter system for murine norovirus to study replication and screen antiviral compounds.

This study shows that lipid asymmetry, mediated by TMEM30a, is essential for murine norovirus entry and persistent infection.

This study shows that glucose and galactose metabolism affects IRF1 stability, which in turn influences vaccinia virus replication outcomes.

This study identifies Cmas and Slc35a1 as host factors required for reovirus binding and infection in murine microglial cells by mediating sialic acid expression.

A genome-wide CRISPR screen with SARS-CoV-2 recovers ACE2 and Cathepsin L and nominates SWI/SNF, TGF-beta signalling and HMGB1 as pro-viral; pathway inhibitors blocked virus-induced death.