This study shows a triple combination of HDAC inhibitor, caging agent, and PEG extends efficacy of a single dose of HDACi for chronic pain treatment in rats.

bioRxiv · Dec 13, 2023 · PreprintNeuroscience

Regulation of neuropathic pain by microglial Orai1 channels

Shogo Tsujikawa, Kaitlyn E. DeMeulenaere, Maria Virginia Centeno, Shahrzad Ghazisaeidi, Megan E. Martin, Martinna G. Raineri Tapies, Mohammad Mehdi Maneshi, Megumi Yamashita, Kenneth A. Stauderman, A. Vania Apkarian, Michael W. Salter, Murali Prakriya

This study shows that Orai1 channels regulate microglial reactivity and neuropathic pain, with sexual dimorphism observed in their effects.

Science Advances · Jan 27, 2023Peer-reviewedNeuroscience

Pattern of Self-Administered Vapor Fentanyl Exposure Determines Long-term Behavior Consequences, in Mice with or without Neuropathic Pain

Samantha Cermak, Maria Virginia Centeno, Rami Jabakhanji, Andrew David Vigotsky, Julia Cox, Andrew Brink, A. Vania Apkarian

This study examines how different fentanyl vapor self-administration regimens affect behavior in mice with and without neuropathic pain, finding regimen-specific outcomes.

bioRxiv · Sep 22, 2022 · PreprintNeuroscience

Dorsal Hippocampal Activation Suppresses Neuropathic Pain Behaviors: Chronic pain as extinction-resistant pain-related memory traces

Wei Xuhong, W. Ren, Maria Virginia Centeno, Daniele Procissi, Ting Xu, Rami Jabakhanji, M. Martina, Jelena Radulović, Dalton James Surmeier, X.G. Liu, A. Vania Apkarian

This study shows that activating the dorsal hippocampus reduces neuropathic pain behaviors through specific neural circuits.

bioRxiv · Mar 30, 2018 · PreprintNeuroscience