This study investigates calcium signaling in Schistosoma mansoni by analyzing STIM and ORAI proteins, identifying pharmacological differences that could enable selective targeting of schistosome calcium channels.

bioRxiv · Aug 5, 2026 · PreprintBiochemistry

Orai1 is required for Ca2+-dependent plasma membrane repair and mechanoadaptation

Haitao Luan, Azize Çerçi, Timothy Alan Bielecki, Bhopal C. Mohapatra, Santosh Shrestha, William Wu, Matthew D. Storck, Lynette M. Smith, Kenneth A. Stauderman, Donald W. Coulter, Anupam Kotwal, Jixin Dong, Jung Yul Lim, Vimla Band, Subramanian P. Ramanathan, Hamid Band

This study identifies Orai1 and EHD2 as essential for Ca2+-dependent plasma membrane repair and mechanoadaptation in response to mechanical injury and bacterial toxins.

bioRxiv · May 15, 2026 · PreprintCell Biology

Regulation of neuropathic pain by microglial Orai1 channels

Shogo Tsujikawa, Kaitlyn E. DeMeulenaere, Maria Virginia Centeno, Shahrzad Ghazisaeidi, Megan E. Martin, Martinna G. Raineri Tapies, Mohammad Mehdi Maneshi, Megumi Yamashita, Kenneth A. Stauderman, A. Vania Apkarian, Michael W. Salter, Murali Prakriya

This study shows that Orai1 channels regulate microglial reactivity and neuropathic pain, with sexual dimorphism observed in their effects.

Science Advances · Jan 27, 2023Peer-reviewedNeuroscience