James Weger‐Lucarelli

This study develops semisynthetic blasticidin S analogs with higher anti-malarial potency and selectivity than the natural product.

This study shows that G-CSF protects against arthritogenic alphavirus disease through type I IFN signaling in mice.

The paper shows that larval environment affects adult mosquito traits and disease transmission through molecular and phenotypic changes.

This study investigates the role of CCL4 and its receptor CCR5 in MAYV infection and finds no significant effect on disease progression or immune response.

This paper identifies auranofin as an effective in vitro inhibitor of HEV, showing antiviral activity against multiple genotypes and a ribavirin-resistant mutant, with ROS-mediated mechanism.

This study uses scRNA-seq to show obesity alters immune cell dynamics and interferon response during alphavirus infection, with lean mice showing a unique macrophage subset that aids in controlling infection.

This study investigates Wolbachia's effect on ZIKV infection in Ae. aegypti using transcriptomics and viral sequencing, finding no clear transcriptional profile or evidence of ZIKV escape.

The paper develops and characterizes infectious clones for two Usutu virus strains, showing they replicate similarly to parental strains in cell cultures and mouse models.

This paper demonstrates that rolling circle amplification (RCA) is a high-fidelity, cost-effective alternative to plasmid preparation for generating infectious viral clones.

This study uses barcoded Zika virus to track genetic bottlenecks during transmission in vitro and in mosquitoes, showing stochasticity in viral dissemination.