Reika Tei

Programming cell behavior with synthetic protease-activated receptors

This paper introduces SynPARs, synthetic protease-activated receptors that enable cells to sense and respond to protease activity, demonstrating their use in counteracting hyperalgesia in mice.

Dynamic network regulating phosphatidic acid homeostasis revealed using membrane editing coupled to proximity labeling

The paper develops a 'Feeding-Fishing' approach to study phosphatidic acid homeostasis by combining membrane editing and proximity labeling, identifying key enzymes and lipid transfer proteins involved in PA metabolism.

Synthetic G protein-coupled receptors for programmable sensing and control of cell behavior

The paper introduces synthetic GPCRs that can be programmed to control cell behavior in response to specific antigens, using modular design for versatile applications.

Ultralow background membrane editors for spatiotemporal control of lipid metabolism and signaling

This paper introduces ultralow background membrane editors for PA that use light to control PLD activity, revealing subcellular differences in PA metabolism and signaling.