Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo
Heegwang Roh, Dongwook Kim, Byeongchan Kim, Younghyeon Jeon, Shreya Malhotra, Hyeonho Kim, Yun-Ju KIM, Martin Jacko, Peter Klein, Chang Lin, Fei Xu, Iván Soltész, Ji Won Um, Alice Y. Ting
This paper introduces LATeNT, a light-activated tetanus neurotoxin that enables conditional proteolysis and inducible synaptic inhibition in vivo, with applications in neuroscience and beta cell function.
Nature Methods · Jul 30, 2026Peer-reviewedBiochemistry