Yuehui Zhao

Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles

This study identifies extreme allelic heterogeneity in the ben-1 gene of C. elegans as a major determinant of natural resistance to albendazole, revealing multiple mechanisms of benzimidazole resistance.

Laboratory evolution from social to solitary behavior in the N2 reference strain is unnecessary for its fitness advantages

This study shows that fitness advantages in the N2 C. elegans strain arise from genetic changes in npr-1 and glb-5, which affect O2 sensing and pheromone circuits, not directly from solitary feeding behavior.