Stefan Zdraljevic

The paper develops a pooled selection platform to map modifiers of RNAi gene knockdown effects in C. elegans, identifying two classes of QTL influencing RNAi responses.

The paper analyzes the genomic diversity of C. tropicalis, finding geographic correlation and hyper-divergent regions linked to environmental adaptation.

The paper analyzes over 2,000 Caenorhabditis briggsae wild strains to uncover genetic diversity, population structure, and evolutionary mechanisms shaping phenotypic variation.

The paper identifies a new TA system in C. elegans with divergent toxin alleles suppressed by distinct mechanisms, including piRNA-mediated silencing in the N2 haplotype.

This study investigates praziquantel's effects on C. elegans development and identifies potential genetic factors, including cct-8, that influence susceptibility.

This paper introduces a method to induce targeted recombination in C. elegans using Cas9, enabling high-resolution genetic mapping in species with low natural recombination rates.

This study evaluates genome-wide association mapping in C. elegans using simulations and a new pipeline, showing increased power with more strains and lower false discovery rates in recently selected populations.

The paper maps eQTLs at cellular resolution in C. elegans using single-cell RNA sequencing, revealing cell-type-specific and single-cell-specific eQTL effects.

The paper identifies a gene, sqst-5, associated with zinc resistance in C. elegans by analyzing genetic variation between strains with different zinc responses.

The paper identifies genetic modifiers of propionate sensitivity in C. elegans using genome-wide association mapping and shows that natural variation in GLCT-3 modulates this trait.

The paper shows that polygenic demographic variation in C. elegans is driven by tightly-linked antagonistic-effect loci, with large-effect variants masked by epistasis or linkage disequilibrium.

This study identifies a nematode-specific gene, scb-1, as a genetic determinant of bleomycin-response variation in C. elegans using linkage mapping and CRISPR-Cas9 experiments.

This study identifies a genetic variant in C. elegans that affects arsenic toxicity through differences in branched-chain amino acid metabolism.

The paper investigates natural variation in sperm size among C. elegans strains and identifies genetic factors, particularly nurf-1, influencing male sperm size and competitive ability.

This study identifies extreme allelic heterogeneity in the ben-1 gene of C. elegans as a major determinant of natural resistance to albendazole, revealing multiple mechanisms of benzimidazole resistance.

The paper identifies QTL associated with benzimidazole resistance in nematodes using genetic mapping and phenotyping.

The paper identifies a single amino acid substitution in topoisomerase II that explains variation in drug sensitivity across C. elegans isolates and human cell lines.

The paper investigates how microtubule function affects cell-to-cell variability in the yeast pheromone response, showing that microtubules stabilize signaling and improve fate decision accuracy.

The paper identifies 50 genes that control cell-to-cell variability in the yeast pheromone response through a high-throughput screen.