Mapping allosteric rewiring in related protein structures from collections of crystallographic multiconformer models
Akshay Raju, Shivani Sharma, Blake T. Riley, Shakhriyor Djuraev, Y.L.K. Tan, Minyoung Kim, Toufique Mahmud, D.A. Keedy
The paper develops RINFAIRE to analyze multiconformer models of PTPs, revealing shared and unique allosteric networks and validating their functional impact through mutations.
bioRxiv · May 23, 2025 · PreprintBiophysics