Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy
Aliki Perdikari, Virgil A. Woods, Ali Ebrahim, Katherine Lawler, Rebecca Bounds, Dinesh Singh Shah, Nathanael I. Singh, Tamar Skaist Mehlman, Blake T. Riley, Shivani Sharma, Jackson W. Morris, Julia M. Keogh, Elana Henning, Miriam Smith, I. Sadaf Farooqi, D. A. Keedy
The paper identifies functional PTP1B variants in thin individuals and uses structural biology to reveal allosteric sites for obesity drug development.
Journal of Biological Chemistry · Oct 23, 2025Peer-reviewedBiophysics