This study enhances iPSC-derived cardiomyocyte maturation by combining 3D culture with a metabolic medium, resulting in improved structural, electrophysiological, and functional characteristics.

bioRxiv · Oct 29, 2025 · PreprintCell Biology

Arrhythpy: An Automated Tool to Quantify and Classify Arrhythmias in Ca2+ Transients of iPSC-Cardiomyocytes

Karim Ajmail, Charlotte Brand, Thomas Borchert, Benjamin Meder, Sabine Rebs, Katrin Streckfuß‐Bömeke

Arrhythpy quantifies and classifies arrhythmias in iPSC-CMs using Ca2+ transients, showing its utility in disease models and drug response analysis.

American Journal of Physiology-Heart and Circulatory Physiology · Sep 15, 2025Peer-reviewedPharmacology & Toxicology

RBM20-variants induce distinct calcium handling and metabolic phenotypes in patient-specific stem cell models of dilated and non-compaction cardiomyopathy

Sabine Rebs, Farbod Sedaghat‐Hamedani, Elham Kayvanpour, Jan Dudek, Branimir Berečić, Hanna Eberl, Daniela Hübscher, Christoph Reich, Teresa Klein, Sören Doose, Viacheslav O. Nikolaev, Kaomei Guan, Gerd P Hasenfuss, Markus Sauer, Malte Tiburcy, , Katrin Streckfuß‐Bömeke

This study compares patient-specific stem cell models of RBM20 mutations causing dilated cardiomyopathy and left ventricular non-compaction, identifying distinct molecular, cellular, and functional impairments.

bioRxiv · Jan 13, 2025 · PreprintMolecular Biology