Katrin Streckfuß‐Bömeke

This study enhances iPSC-derived cardiomyocyte maturation by combining 3D culture with a metabolic medium, resulting in improved structural, electrophysiological, and functional characteristics.

This study shows that peroxisome dysfunction in mice and engineered human myocardium leads to heart failure through metabolic impairment and disrupted cellular respiration.

Arrhythpy quantifies and classifies arrhythmias in iPSC-CMs using Ca2+ transients, showing its utility in disease models and drug response analysis.

This study compares patient-specific stem cell models of RBM20 mutations causing dilated cardiomyopathy and left ventricular non-compaction, identifying distinct molecular, cellular, and functional impairments.

The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.

This study introduces a novel single-cell RNA-sequencing platform and applies it to analyze genotype-phenotype relationships in ageing disorders.