Nazmus Salehin

Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst

The paper shows that inhibiting ERK signaling expands epiblast cells capable of becoming naive pluripotent stem cells in humans, while FGF stimulation expands hypoblast markers.

MIXL1 Activation in Endoderm Differentiation ofHuman Induced Pluripotent Stem Cells

The paper shows that activating MIXL1 in hiPSCs improves endoderm differentiation and maturation.

Characterization of the mesendoderm progenitors in the gastrulating mouse embryo

The paper identifies mesendoderm progenitor cells in mouse embryos and shows their contribution to endoderm and mesoderm lineages through lineage tracing and analysis of Mixl1 function.

Systematic evaluation of blastoid models of early human development

This study evaluates blastoid models of early human development by comparing them to a reference map of human blastocysts, identifying their lineage coverage and differentiation progression.

Deep Learning Based Models for Preimplantation Mouse and Human Development

This paper uses deep learning to classify and integrate single-cell transcriptomic data from mouse and human preimplantation embryos, defining cell types and states.

Transcription Factor Co-Expression Mediates Lineage Priming for Embryonic and Extra-Embryonic Differentiation

The paper identifies ESCs co-expressing GATA6 and SOX2, showing their cooperative DNA binding in enhancers and role in lineage priming for embryonic and extra-embryonic differentiation.