Silas Boye Nissen

Cluster Assembly Dynamics Drive Fidelity of Planar Cell Polarity Polarization

The paper investigates how cluster assembly dynamics contribute to planar cell polarity polarization by analyzing protein monomer counts in live animals and using mathematical modeling.

Cell autonomous polarization by the planar cell polarity signaling pathway

This study shows that Planar Cell Polarity (PCP) signaling can polarize cells autonomously, without requiring intercellular feedback, and identifies feedback pathways that operate cell-autonomously.

Protein phosphatase 1 regulates core PCP signaling

The paper identifies Pp1-87B as a regulator of core PCP signaling by modulating Van Gogh subcellular localization and dephosphorylation in Drosophila wings.

Transcriptional Heterogeneity and Cell Cycle Regulation as Central Determinants of Primitive Endoderm Priming.

The paper investigates how cell cycle regulation influences transcriptional heterogeneity and lineage priming in embryonic stem cells differentiating into primitive endoderm.

Model to link cell shape and polarity with organogenesis

The paper challenges the two-step model of tube formation by showing that either cell intercalation or wedging alone can suffice for the sheet-to-tube transition, supported by simulations of Drosophila, Sea urchin, and mammalian systems.