Author

Christine A. Sedore

University of OregonORCID 0000-0002-9512-2806Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Physiology· 1

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Organism:C. elegans· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Anna L Coleman-HulbertiD· 2 shared Erik JohnsoniD· 2 shared Erik SegerdelliD· 2 shared Gordon J. LithgowiD· 2 shared Monica DriscolliD· 2 shared Patrick C. PhillipsiD· 2 shared Anna FoulgeriD· 1 shared Brian OnkeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Anna L Coleman-HulbertORCID

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2 papers

Recent·Most cited

The broccoli derivative sulforaphane extends lifespan by slowing the transcriptional aging clock

Christine A. Sedore, Erik Segerdell, Anna L Coleman-Hulbert, Erik Johnson, Jonathan N. Levi, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips

This study shows sulforaphane extends C. elegans lifespan by over 50% when administered early and reduces transcriptional age by 20%.

PLOS Aging and Health · Oct 27, 2026Peer-reviewedPhysiology

Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

Stephen A. Banse, Christine A. Sedore, Anna L Coleman-Hulbert, Erik Johnson, Brian Onken, David Hall, Erik Segerdell, E Grace Jones, Yuhua Song, Hadley Osman, Jian Xue, Elena Battistoni, Suzhen Guo, Anna Foulger, Madhuri Achanta, , Patrick C. Phillips

The paper identifies retinoic acid modulation as a driver of longevity pathways in C. elegans using computational predictions and genetic analysis of 16 compounds.

eLife · Dec 23, 2025Peer-reviewedGenetics