Gordon J. Lithgow

This study shows sulforaphane extends C. elegans lifespan by over 50% when administered early and reduces transcriptional age by 20%.

The paper introduces PickliPy, an open-source framework for converting assay designs into ADE picklists, enabling reproducible and scalable microplate-based experiments.

The paper investigates how Anle138b coordination with silver affects alpha-synuclein aggregation, showing reduced C-terminal truncation and increased aggregate size.

This study shows that human brain aging involves asymmetric remodeling of the insoluble proteome, with intermediate-stability aggregates accumulating and being linked to neurodegenerative disease.

This study shows that restoring ribosomal homeostasis by targeting RNAse P/MRP or mitochondrial ribosome extends lifespan in C. elegans by improving proteostasis and ribosome assembly.

The paper identifies retinoic acid modulation as a driver of longevity pathways in C. elegans using computational predictions and genetic analysis of 16 compounds.

This study investigates how acute exercise affects proteostasis pathways in C. elegans, finding increased proteasomal activity, autophagic flux, and lifespan extension.

This study identifies new kinases modulating insulin signaling and longevity in C. elegans through a kinome-wide RNAi screen, revealing correlations between thermotolerance, dauer formation, and lifespan extension.

This study shows that amyloid β accelerates age-related protein insolubility in C. elegans and links this process to neurodegenerative and age-related diseases through proteomics and GWAS.

This study identifies MG-H1 as a mediator of increased food intake in C. elegans glod-4 mutants through a tyramine signaling pathway regulated by the GATA transcription factor ELT-3.

This study shows that expressing human amyloid-β and Tau in C. elegans neurons causes phenotypic and multi-omic changes, including accelerated aging and metabolic dysfunction.