Jonathan N. Levi

The broccoli derivative sulforaphane extends lifespan by slowing the transcriptional aging clock

This study shows sulforaphane extends C. elegans lifespan by over 50% when administered early and reduces transcriptional age by 20%.

A Bioprinted Head and Neck Cancer Organoid-Based Platform for Evaluating Multimodal Therapies

This paper develops a bioprinted organoid platform to evaluate multimodal therapies for HNSCC, showing differential responses to radiosensitizers in patient-derived models.

Single cell profiling reveals GSM-15606 attenuates air pollution-induced inflammation and preserves hippocampal neurogenesis

The paper uses single-cell RNA sequencing to show GSM-15606 reduces inflammation and preserves neurogenesis in the hippocampus of mice exposed to air pollution.

Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas

This study uses patient-derived organoids to model pheochromocytomas and paragangliomas, revealing hypoxia-driven plasticity and therapeutic vulnerabilities, including responses to abemaciclib.

Inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet.

This study shows that inhibiting a non-canonical gp130 signaling pathway reduces chronic inflammation and multimorbidity in a high-fat diet model.