Anna Foulger

This study shows that human brain aging involves asymmetric remodeling of the insoluble proteome, with intermediate-stability aggregates accumulating and being linked to neurodegenerative disease.

The paper identifies retinoic acid modulation as a driver of longevity pathways in C. elegans using computational predictions and genetic analysis of 16 compounds.

This study identifies new kinases modulating insulin signaling and longevity in C. elegans through a kinome-wide RNAi screen, revealing correlations between thermotolerance, dauer formation, and lifespan extension.

This study shows that amyloid β accelerates age-related protein insolubility in C. elegans and links this process to neurodegenerative and age-related diseases through proteomics and GWAS.

This study shows that expressing human amyloid-β and Tau in C. elegans neurons causes phenotypic and multi-omic changes, including accelerated aging and metabolic dysfunction.