Patrick C. Phillips

The broccoli derivative sulforaphane extends lifespan by slowing the transcriptional aging clock

This study shows sulforaphane extends C. elegans lifespan by over 50% when administered early and reduces transcriptional age by 20%.

Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan

The paper tests pro-longevity compounds on C. elegans males, finding lifespan extension in all tested conditions but only two compounds improved reproductive healthspan.

Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

The paper identifies retinoic acid modulation as a driver of longevity pathways in C. elegans using computational predictions and genetic analysis of 16 compounds.

Disruption of the insulin signaling pathway in C. elegans dramatically increases male longevity and enhances reproductive health late in life

This study shows that disrupting the insulin signaling pathway in male C. elegans significantly increases lifespan and improves reproductive health late in life.

Gene expression variation across genetically identical individuals predicts reproductive traits

This study identifies gene expression variation in genetically identical C. elegans that predicts reproductive traits and shows some variation is causal and influenced by chromatin structure.

Precise Lineage Tracking Using Molecular Barcodes Demonstrates Fitness Trade-offs for Ivermectin Resistance in Nematodes

This study uses molecular barcoding in C. elegans to measure fitness trade-offs of ivermectin resistance across varying drug concentrations.

Pervasive conservation of intron number and other genetic elements revealed by a chromosome-level genomic assembly of the hyper-polymorphic nematode Caenorhabditis brenneri

This study presents a chromosome-level genome assembly of C. brenneri, revealing conserved intron number patterns and genome organization despite high genetic diversity.

Widespread changes in gene expression accompany body size evolution in nematodes

The paper compares gene expression patterns between C. elegans and C. inopinata during larval-to-adult development to identify transcriptional changes associated with body size evolution.

High-Throughput Library Transgenesis in Caenorhabditis elegans via Transgenic Arrays Resulting in Diversity of Integrated Sequences (TARDIS)

The paper introduces TARDIS, a high-throughput transgenesis method in C. elegans that generates thousands of genetically unique transgenic individuals by splitting the transgenesis process into two steps.

Rapid self-selecting and clone free integration of transgenes into engineered CRISPR safe harbor locations in Caenorhabditis elegans

This paper introduces a CRISPR-based method for rapid, clone-free transgene integration in C. elegans without molecular validation or anti-array screening.

Chromosome-level assembly of the Caenorhabditis remanei genome reveals conserved patterns of nematode genome organization

The paper presents a chromosome-level genome assembly of C. remanei using long-read sequencing and chromatin conformation capture, revealing conserved genomic organization patterns with C. elegans.

Auxin-Mediated Sterility Induction System for Longevity and Mating Studies in Caenorhabditis elegans

This paper introduces an auxin-mediated sterility induction system in C. elegans that allows reversible control of fertility, offering advantages over existing methods for studying mating systems and aging.