Monica Driscoll

The broccoli derivative sulforaphane extends lifespan by slowing the transcriptional aging clock

This study shows sulforaphane extends C. elegans lifespan by over 50% when administered early and reduces transcriptional age by 20%.

Condensate Material Properties Influence Cargo Selection for Neuronal Extrusion via Large Extracellular Exopher Vesicles

The paper investigates how condensate material properties affect exopher cargo selection in neurons, finding that gel-like condensates are more efficiently recruited than liquid-like ones.

Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

The paper identifies retinoic acid modulation as a driver of longevity pathways in C. elegans using computational predictions and genetic analysis of 16 compounds.

Analysis of Categorical Data with Logistic Regression and the Cochran-Mantel-Haenszel Tests in Biological Experiments

The paper provides a practical guide for analyzing categorical data in biological experiments using logistic regression and the Cochran-Mantel-Haenszel tests, with examples from Caenorhabditis elegans research.

Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons

The paper shows that mechanical uterine distention enhances exopher extrusion from proteostressed C. elegans neurons, linking mechanical force to extracellular vesicle production and neurodegenerative disease mechanisms.

Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell

The paper investigates the fate of exophers in C. elegans, showing they are engulfed and degraded by hypodermal cells through a phagocytic process involving specific molecular factors.

Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans

This study shows that spaceflight causes dendritic remodeling and impaired clearance of neuronal debris in adult C. elegans neurons.

Swim exercise in C. elegans extends neuromuscular and intestinal healthspan, enhances learning ability, and protects against neurodegeneration

This study shows that swim exercise in C. elegans improves healthspan and protects against neurodegeneration, even when exercise stops early in adulthood.

Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans

This paper introduces a Pluronic gel-based burrowing assay to assess neuromuscular health in C. elegans by measuring their ability to navigate a gel environment.

pals-22, A Member Of An Expanded C. elegans Gene Family, Controls Silencing Of Repetitive DNA

The paper identifies pals-22 as a gene required to prevent silencing of repetitive transgenes in C. elegans somatic tissues and links it to RNAi-dependent mechanisms.