John R. Horton

This paper investigates the DNA-binding properties of BCL11B's bipartite zinc finger domain and its mutations linked to neurodevelopmental disorders.

This study investigates BCL11A DNA binding mechanisms, epigenetic regulation, and small-molecule effects on its expression in human erythrocyte precursor cells.

This paper determines the structure of HELLS in its autoinhibitory state and shows how CDCA7 and DNA activate it.

The paper determines the structure of HPAMPD, a mollusk adenosine deaminase with nucleotide specificity, and shows how it binds the 5-monophosphate group of AMP through specific structural elements.

This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.

The paper identifies a unique DNA-binding domain in CDCA7 that recognizes a CpG dyad in non-B DNA, linking it to DNA methylation specificity in ICF syndrome.

The paper identifies ZNF410 as a highly specific transcriptional activator in erythroid cells that regulates CHD4 and fetal hemoglobin expression.