Combination Treatment with Sclerostin and Dkk1 Antibodies Synergizes with Tibial Loading to Stimulate Bone Formation in Aged Mice
Lisa Y. Lawson, Christopher J. Chermside‐Scabbo, Michael D. Brodt, Nicole Migotsky, John T. Shuster, Evan G. Buettmann, Matthew J. Silva
This study shows that combining Sclerostin and Dkk1 antibodies with mechanical loading significantly enhances bone formation in aged mice.
bioRxiv · Feb 24, 2026 · PreprintPhysiology