Jan Wijnholds

This study shows that deleting Phd2 in Crb1/Crb2-deficient mice partially improves retinal function and structure but does not correct underlying defects.

This study demonstrates that high-capacity adenoviral vectors can restore USH2A protein expression and its interacting partners in USH2A-defective retinal organoids.

This study uses hiPSC-derived retinal organoids to show that ABCA4 loss in photoreceptors disrupts glial cell homeostasis, suggesting a role for glial cells in Stargardt disease progression.

This study evaluates gene supplementation of MYO7A via dual AAVs and CRISPR/Cas activation of Myo7b in animal models and human retinal organoids to treat Usher syndrome 1B.

The paper shows that Crumbs2 (CRB2) mediates dorsal collapse in the spinal cord by promoting cell delamination and ventricular layer remodelling.