Metabolic pathway competition sensitizes thioredoxin reductase-depleted Candida albicans to cell wall stress and antifungals
Wanjun Qi, Udita Roy, Chunhui Cai, Maikel Acosta‐Zaldívar, Jossalyn Mascio, John M. Asara, José F. Fierro, María Teresa Ainaga Andrés, Liang Sun, Julia R. Köhler
This study shows that Trr1 depletion in C. albicans increases sensitivity to antifungals and cell wall stress by disrupting metabolic pathways and cell wall synthesis.
bioRxiv · Dec 3, 2025 · PreprintMicrobiology