Author

Joseph H. Nadeau

Maine Medical Center Research InstituteORCID 0000-0002-9570-7361Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Alessandro MichelucciiD· 2 shared Heike KollmusiD· 2 shared Klaus SchughartiD· 2 shared Lasse SinkkoneniD· 2 shared Manuel ButtiniiD· 2 shared Mélanie H. ThomasiD· 2 shared Michel Guy André MittelbronniD· 2 shared Mona KaroutiD· 2 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Alessandro MichelucciORCID

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4 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJun 1, 2025

BifurcatoR: A Framework for Revealing Clinically Actionable Signal in Variance Masquerading as Noise

Zachary Madaj, Mao Ding, Carmen Khoo…·Timothy J. Triche

BifurcatoR identifies clinically relevant subgroups by analyzing variance patterns in biological data, revealing hidden structures in AML and obesity.

DOI 10.1101/2025.06.01.657083

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsFrontiers in GeneticsPeer-reviewedSep 23, 2020

Pituitary Tumor Transforming Gene 1 orchestrates gene regulatory variation in mouse ventral midbrain during aging

Yujuan Gui, Mélanie H. Thomas, Pierre Garcia…·Lasse Sinkkonen

The paper identifies Pttg1 as a key regulator of gene expression variation in mouse ventral midbrain across aging, showing its role in transcriptome shifts and cell-type-specific changes.

6 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 28, 2020

Quantitative trait locus mapping identifies Col4a6 as a novel regulator of striatal dopamine level and axonal branching in mice.

Mélanie H. Thomas, Yujuan Gui, Pierre Garcia…·Manuel Buttini

The paper identifies Col4a6 as a genetic regulator of striatal dopamine levels and axonal branching in mice through QTL mapping and RNA-seq analysis.

DOI 10.1101/2020.06.28.176206

mousebulk RNA-seq

𝕏 PostBluesky

GeneticsbioRxivPreprintApr 13, 2017

Do gametes woo? Evidence for non-random unions at fertilization

Joseph H. Nadeau

The paper investigates non-random fertilization in mice, showing that certain genes and diets can bias genotype combinations at fertilization, challenging the assumption of random genetic combination.

4 citations

mouse

𝕏 PostBluesky