Mélanie H. Thomas

This study shows that dietary fibre deprivation and bacterial curli exposure worsen PD-like symptoms in mice overexpressing human alpha-synuclein.

The paper profiles chromatin accessibility in ventral midbrain single nuclei from two mouse strains, identifies cell types and transcription factors, and finds regulatory variation specific to cell types.

This study examines age-related changes in the nigro-striatal circuit across three mouse strains, revealing strain-specific differences in dopaminergic neuron integrity and highlighting the importance of considering strain and age in Parkinson's disease research.

The paper identifies Pttg1 as a key regulator of gene expression variation in mouse ventral midbrain across aging, showing its role in transcriptome shifts and cell-type-specific changes.

The paper identifies Col4a6 as a genetic regulator of striatal dopamine levels and axonal branching in mice through QTL mapping and RNA-seq analysis.