Yujuan Gui

The paper introduces BoNesis, a tool for inferring Boolean networks from transcriptome data to model cellular differentiation and reprogramming, demonstrating its application in hematopoiesis and adipocyte/osteoblast differentiation.

The paper shows that Park7 deletion causes sex-specific transcriptome changes in male mouse midbrain astrocytes via the NRF2-CYP1B1 axis, affecting oxidative stress and EMT processes.

The paper profiles chromatin accessibility in ventral midbrain single nuclei from two mouse strains, identifies cell types and transcription factors, and finds regulatory variation specific to cell types.

This study examines age-related changes in the nigro-striatal circuit across three mouse strains, revealing strain-specific differences in dopaminergic neuron integrity and highlighting the importance of considering strain and age in Parkinson's disease research.

The paper identifies Pttg1 as a key regulator of gene expression variation in mouse ventral midbrain across aging, showing its role in transcriptome shifts and cell-type-specific changes.

The paper identifies Col4a6 as a genetic regulator of striatal dopamine levels and axonal branching in mice through QTL mapping and RNA-seq analysis.

This study shows that excess fetal GDNF can prolong nephrogenesis in postnatal mouse kidneys without increasing tumor risk.