Circuit-based intervention corrects excessive dentate gyrus output in the Fragile X mouse model
Pan‐Yue Deng, Ajeet Kumar, Valeria Cavalli, Vitaly A. Klyachko
The paper identifies mossy cell hypo-excitability in FXS due to increased Kv7 function and shows that circuit-based Kv7 inhibition normalizes dentate output.
bioRxiv · Sep 27, 2023 · PreprintNeuroscience