Vitaly A. Klyachko

This study identifies Fibulin-2 released by satellite glial cells as a regulator of sensory neuron excitability, with implications for pain management.

This study shows astrocytic cholesterol regulates synaptic exo- and endocytosis balance by modulating release modes and spatial organization.

The paper shows the ketogenic diet reduces excitatory synaptic gain by shrinking synaptic vesicle pools through transcriptional and epigenetic changes in the hippocampus.

This study shows that pyruvate supports neuronal viability without glucose and that mitochondrial pyruvate uptake regulates synaptic transmission in hippocampal terminals.

The paper shows that mitochondria, not glycolysis, regulate vesicle release probability and location in hippocampal synapses, and that mitochondrial inhibition increases ultrafast endocytosis.

This study shows that Sirt3 is induced during glucose deprivation and supports synaptic transmission by enhancing mitochondrial function and synaptic vesicle recycling.

The paper identifies mossy cell hypo-excitability in FXS due to increased Kv7 function and shows that circuit-based Kv7 inhibition normalizes dentate output.

The paper identifies two distinct subpopulations of asynchronous release events in hippocampal synapses with different spatiotemporal dynamics and endocytic coupling.

This study shows that myosin V regulates the spatial distribution of neurotransmitter release sites in central synapses, affecting both uni-vesicular and multi-vesicular release.

This study identifies fatty acid synthesis in satellite glial cells as a mechanism promoting axon regeneration after nerve injury.

The paper investigates the spatiotemporal dynamics of multi-vesicular release (MVR) in synapses, revealing heterogeneous release site properties and their regulation by calcium gradients.