Jagdeep Nanchahal

ORBIT integrates omics data across studies and layers to identify convergent disease mechanisms by prioritizing concordant signals using rank-based methods.

The paper identifies ThrEDs, a novel type of extracellular particle that accelerates wound healing and reduces fibrotic responses in patient-derived myofibroblasts.

This study creates a spatial genomics atlas of human skin fibroblasts in health and disease, identifying six major populations and three disease-specific subtypes.