Xue Li

Measuring Growth, Resistance and Recovery after Artemisinin Treatment of Plasmodium falciparum in a semi-high-throughput Assay

This paper develops and validates a qPCR-based assay to measure growth, resistance, and recovery of Plasmodium falciparum after artemisinin treatment, showing distinct phenotypes with independent genetic determinants.

Pooled long-read sequencing for structural variant characterization in schistosome populations

This study uses pooled long-read sequencing to identify and genotype 17,446 structural variants in five Schistosoma mansoni populations, revealing population-specific variants and associations with biomedically relevant traits.

Rapid phenotypic and genotypic change in a laboratory schistosome population

The paper detects recent contamination in a laboratory Schistosoma mansoni population and shows how genetic drift causes divergence in parasite populations over time.

Using a P. falciparum genetic cross to dissect the relative contributions of pfcrt and plasmepsin II/III to piperaquine response-related traits

This study uses a genetic cross of Plasmodium falciparum isolates to analyze the roles of pfcrt and pm2/3 in piperaquine resistance and fitness traits.

An amino acid transporter AAT1 plays a pivotal role in chloroquine resistance evolution in malaria parasites

This study identifies pfaat1 as a key gene in chloroquine resistance evolution in malaria parasites, showing it modulates resistance and fitness through amino acid transport.

Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice

This study optimizes bulk segregant analysis for identifying drug resistance loci in Plasmodium falciparum using genetic crosses in humanized mice, confirming the kelch13 locus and demonstrating the utility of cryopreserved pools.

Efficient transcriptome profiling across the malaria parasite erythrocytic cycle by flow sorting

This paper develops a method to efficiently profile the transcriptome of the malaria parasite Plasmodium falciparum across its erythrocytic cycle using flow sorting.

Bulk segregant analysis reveals environment x genotype interactions determining malaria parasite growth

The paper uses bulk segregant analysis to identify genetic loci affecting malaria parasite growth in different media, finding EBA-140 as a key gene involved in media-dependent fitness.

Surprising variation in the outcome of two malaria genetic crosses using humanized mice: implications for genetic mapping and malaria biology

The paper reports two new genetic crosses of Plasmodium falciparum in humanized mice, showing significant variation in marker segregation and demonstrating improved power for genetic mapping of malaria traits.