David W. H. Riches

Dynamic hybrid-hydrogel lung models decouple matrix composition, stiffness, and fibroblast conditioning to define distinct drivers of fibrotic progression

This study uses 3D lung models to show that environmental stiffness has the strongest effect on fibroblast phenotype and that both matrix composition and stiffness influence gene expression in fibrotic disease.

Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosis

This paper develops 3D human lung models using biomaterials to replicate early pulmonary fibrosis features and tests drug responses.