Chelsea M. Magin

This study develops sex- and disease-informed biomaterial design criteria from human lung tissue to create engineered hybrid-hydrogels that recapitulate mechanical and biochemical features of IPF.

This study uses 3D lung models to show that environmental stiffness has the strongest effect on fibroblast phenotype and that both matrix composition and stiffness influence gene expression in fibrotic disease.

This study identifies sex-biased protein expression in healthy and fibrotic human lung regions, highlighting potential biological mechanisms for sex differences in idiopathic pulmonary fibrosis.

This paper develops a hydrogel-embedded PCLS model to study pulmonary fibrosis, showing prolonged viability and matching fibrotic gene expression patterns in human tissue.

This study shows that hydrogel-embedded precision-cut lung slices can maintain premalignant lung lesions for six weeks and respond to a cancer prevention agent.

This study identifies proteomic changes in non-fibrotic lung tissue associated with the MUC5B promoter variant, linking them to fibrosis progression.

This paper develops a 3D-bioprinted model of pulmonary artery adventitia using female patient-derived cells to show that estrogen signaling mediates fibroblast activation in PAH, with implications for drug testing.

This paper develops 3D human lung models using biomaterials to replicate early pulmonary fibrosis features and tests drug responses.

This study shows engineered hydrogels improve lung progenitor cell differentiation from iPSCs compared to Matrigel, offering a more defined and controllable method for clinical applications.