Author

Y. Esther Tak

Harvard UniversityORCID 0000-0002-9588-1626Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:Hi-C· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

J. Keith JoungiD· 2 shared Anders S. HanseniD· 1 shared Christian G. Cerda-SmithiD· 1 shared Christine Elissa EyleriD· 1 shared Corriene E. Sept· 1 shared Haley M. HutchinsoniD· 1 shared Hayley T. SchultziD· 1 shared Ivy T. Nguyen· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

J. Keith JoungORCID

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2 papers

Recent·Most cited

CRISPR PERSIST-On enables heritable and fine-tunable human gene activation

Y. Esther Tak, Jonathan Y. Hsu, Justine Shih, Hayley T. Schultz, Ivy T. Nguyen, Kin Chung Lam, Luca Pinello, J. Keith Joung

The paper introduces PERSIST-On, a CRISPR-based method for stable and tunable gene activation by recruiting endogenous transcription factors to target promoters.

bioRxiv · Apr 26, 2024 · PreprintMolecular Biology

High-resolution CTCF footprinting reveals impact of chromatin state on cohesin extrusion dynamics

Corriene E. Sept, Y. Esther Tak, Christian G. Cerda-Smith, Haley M. Hutchinson, Viraat Y. Goel, Marco Blanchette, Mital S. Bhakta, Anders S. Hansen, J. Keith Joung, Sarah E. Johnstone, Christine Elissa Eyler, Martin J. Aryee

The paper uses high-resolution CTCF MNase HiChIP data to analyze chromatin loop structures and introduces FactorFinder, finding that fully extruded CTCF-CTCF loops are rare and that chromatin state affects cohesin extrusion dynamics.

bioRxiv · Oct 20, 2023 · PreprintGenomics