Author
Massachusetts General HospitalORCID 0000-0001-9297-5208Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Y. Esther Tak, Jonathan Y. Hsu, Justine Shih…·J. Keith Joung
The paper introduces PERSIST-On, a CRISPR-based method for stable and tunable gene activation by recruiting endogenous transcription factors to target promoters.
Jonathan Y. Hsu, Kin Chung Lam, Justine Shih…·J. Keith Joung
MOSAIC enables high-throughput in situ saturation mutagenesis and CRISPR prime editing guide RNA optimization in human cells, identifying optimized pegRNAs and drug resistance variants.
Jonathan Y. Hsu, Julian Grünewald, Regan N. Szalay…·Luca Pinello
PrimeDesign is a tool for designing prime editing guide RNAs, enabling single and combination edits, and it supports the creation of a database for over 68,500 pathogenic variants.