Viraat Y. Goel

The paper identifies 'matchmaker' cis-regulatory elements in erythropoiesis that strengthen loops between neighboring elements and are linked to gene expression and cohesin loading.

The paper identifies ZNF654 and JMJD6 as novel factors defining TAD boundaries through in silico screens and experimental validation.

The paper uses Region Capture Micro-C to study microcompartment formation during mitosis-to-G1 transition, finding they form in prometaphase and are influenced by chromatin compaction and loop extrusion.

This study shows LDB1 directly promotes enhancer-promoter loops and organizes multi-enhancer networks to activate transcription, independent of CTCF, cohesin, or YY1.

The paper uses high-resolution CTCF MNase HiChIP data to analyze chromatin loop structures and introduces FactorFinder, finding that fully extruded CTCF-CTCF loops are rare and that chromatin state affects cohesin extrusion dynamics.

The paper identifies 10 PTEN enhancers and proposes a new model of enhancer organization that includes spatial separation of functional and structural elements.

The paper introduces RCMC, a method to capture deep 3D genome structure, revealing microcompartments where enhancers and promoters coalesce.