Srinidhi Varadharajan

Dominant Malignant Clones Leverage Lineage Restricted Epigenomic Programs to Drive Ependymoma Development

This study identifies specific developmental epigenomic states that enable ZFTA-RELA-driven ependymoma formation and reveals how these states shape tumor progression.

Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology

The paper constructs a transcriptomic landscape for medulloblastoma and ependymoma, revealing subtype-specific biology through clustering and molecular signatures.

Genome sequencing of the nine-spined stickleback (Pungitius pungitius) provides insights into chromosome evolution.

The paper presents a high-quality chromosome-level genome assembly of the nine-spined stickleback, revealing evolutionary insights and chromosomal rearrangements compared to the three-spined stickleback.

The grayling genome reveals selection on gene expression regulation after whole genome duplication

The paper analyzes the grayling genome to study regulatory divergence of Ss4R duplicates after whole genome duplication, finding purifying selection and adaptive divergence in brain-related and immune functions.