Joel G. Hashimoto

Astrocyte Reactivity by Alcohol Dependence in the Central Amygdala

This study identifies astrocyte reactivity in the central amygdala due to ethanol dependence through multi-omics analysis in mice, revealing adaptive and maladaptive changes in neuroimmune and cytoskeletal pathways.

Chronic Ethanol Drinking Alters Medial Prefrontal Cortex and Nucleus Accumbens Astrocyte Translatome and Extracellular Matrix Glycosaminoglycans

This study identifies sex- and region-specific astrocyte molecular changes in response to chronic ethanol, highlighting extracellular matrix and glycosaminoglycan remodeling as key factors in ethanol-related neuroplasticity.

Alcohol Dependence-Induced Astrocyte Immune Activation in the Nucleus Accumbens

This study identifies astrocyte-specific gene and pathway changes in the nucleus accumbens during alcohol dependence using RNA-Seq and TRAP, revealing distinct immune activation patterns compared to ethanol drinking.

Changes in nucleus accumbens core translatome accompanying incubation of cocaine craving

This study identifies translating mRNAs linked to incubation of cocaine craving in specific nucleus accumbens core neurons using TRAP-seq in transgenic rats.

Astrocyte extracellular matrix modulates neuronal dendritic development

The paper shows that ethanol inhibits astrocyte translation of Chpf2 and Chsy1, reducing CS-GAGs and increasing dendritic arborization in hippocampal neurons.