Xiaobin Zheng

Lamins promote trophoblast lineage-associated transcription and trophoblast giant cell development in placental organogenesis

This study shows lamins are essential for placental development by supporting trophoblast giant cell polyploidization and lineage-specific gene expression.

Lamins gate nuclear and chromatin structures for cardiomyocyte maturation genes

This study shows lamin-B1 is essential for cardiomyocyte maturation and survival by maintaining chromatin organization and transcription programs during heart development.

Lamins and lineage-relevant transcription factors coordinate gene expression in lineage development

The paper shows that lamins A and B1 maintain LADs and gene expression in yolk sac endoderm by interacting with transcription factors.

A model-based analysis reveals three-dimensional genome organization heterogeneity and functional sub-compartments in cell populations

The paper introduces CscoreTool-M, a model-based method for inferring 3D genome sub-compartments from Hi-C data, showing higher accuracy in identifying heterochromatin regions and quantifying sub-compartment heterogeneity in cell populations.

High quality mapping of chromatin at or near the nuclear lamina for small numbers of cells

This paper introduces cTSA-seq, a method to map chromatin near the nuclear lamina from small cell numbers, revealing insights into chromatin organization during early G1 and senescent cells.

aFARP-ChIP-seq, a convenient and reliable method for genome profiling in as few as 100 cells with a capability for multiplexing ChIP-seq

aFARP-ChIP-seq enables genome-wide profiling of histone modifications and transcription factor binding sites in as few as 100 cells with multiplexing capability.

Lamins organize the global three-dimensional genome from the nuclear periphery

This study shows that lamins maintain TAD-TAD interactions and regulate chromatin domain interactions, which are correlated with transcription changes in mouse ES cells.

CscoreTool: Fast Hi-C Compartment Analysis at High Resolution

CscoreTool provides a fast and memory-efficient method for high-resolution A/B compartment analysis from Hi-C data, even with low sequencing depth.