Robert D. Goldman

This study shows that vimentin expression in breast cancer cells changes 3D cluster morphology, enhances migration, and increases cell-matrix interactions.

FilaBuster enables rapid, specific, and spatiotemporally controlled disassembly of intermediate filaments in living cells using a three-step photochemical strategy.

This study shows vimentin forms liquid droplets that stabilize actin fibers by wetting them, and this behavior is observed in both a mutant and wild-type vimentin.

The paper uses single-cell RNA sequencing to study ductus arteriosus closure in mice, identifying vimentin as critical for vascular remodeling and closure.

This paper introduces cTSA-seq, a method to map chromatin near the nuclear lamina from small cell numbers, revealing insights into chromatin organization during early G1 and senescent cells.

The paper introduces an image analysis method to segment filamentous structures and their intersections in microscopy images by resolving multiple orientations.

The paper introduces TSA-Seq, a method to measure chromosomal distances to nuclear structures and reveals a spatial gradient in genome activity correlated with nuclear compartments.

This study shows that both vimentin and keratin intermediate filaments are transported along microtubules via kinesin-1, independent of kinesin light chains, revealing a unified transport mechanism.