Cancer BiologybioRxivPreprint
The E2F4 transcriptional repressor is a key mechanistic regulator of colon cancer resistance to irinotecan (CPT-11).
Junichi Matsubara, Yong Fuga Li, Sanjay Koul…·Piero D. Dalerba
This study identifies E2F4 as a key regulator of colon cancer resistance to irinotecan by showing its role in drug resistance through shRNA knockdown in PDX models.