Debashis Sahoo

This study shows that Catestatin improves heart metabolic flexibility by enhancing mitochondrial structure and function through binding to ATP synthase.

This study shows that Catestatin reduces Tau pathology and amyloid plaque formation by inhibiting adrenergic signaling in mouse models of neurodegenerative diseases.

This study investigates age-related changes in germline stem cells (GSCs) in the protochordate Botryllus schlosseri using single-cell RNA sequencing and transplantation assays, revealing that GSCs, not gametes, drive reproductive aging.

The paper shows that pulsatile electrical current improves survival, regeneration, and reproduction in Botryllus schlosseri by altering stem cell and immune activity through transcriptomic changes.

This study identifies E2F4 as a key regulator of colon cancer resistance to irinotecan by showing its role in drug resistance through shRNA knockdown in PDX models.

The paper identifies a Microbe-Associated Colorectal Cancer Signature (MACS) induced by Fusobacterium nucleatum in genetically predisposed hosts, linking microbial infection to early CRC initiation.

This study investigates the relationship between placental and lung macrophage polarization and their role in the development of bronchopulmonary dysplasia.

This study identifies C1QA as a consistent biomarker for tissue macrophages and explores its role in anti-microbial pathways.

The paper refines a gene signature for identifying TAM polarization in CRC using single-cell RNA-seq and transfer learning, validated across multiple datasets.

The paper identifies a 338-gene signature of macrophage reactivity and tolerance that predicts disease outcomes across diverse conditions and species.

The paper develops predictive models of gastric cancer progression using Boolean implication networks and identifies gene clusters associated with different stages of the disease.

The paper uses BoNE to identify dual PPARα/γ agonism as a therapeutic strategy for IBD, validated in preclinical models and patient-derived cells.

The paper identifies a conserved 166-gene host immune signature across viral pandemics, with a 20-gene subset predicting disease severity and guiding therapeutic strategies.

The paper introduces iDEA, a method to improve differential expression analysis in cancer, revealing mechanisms of resistance to cell cycle inhibitors in retinoblastoma.

The paper identifies age-specific circadian gene expression patterns in Botryllus schlosseri and links them to aging phenotypes and pathways.

The paper introduces a Boolean implication analysis method to improve prediction accuracy of retinal cell type-specific genes using single cell RNA-sequencing data.