Yong Fuga Li

This study identifies E2F4 as a key regulator of colon cancer resistance to irinotecan by showing its role in drug resistance through shRNA knockdown in PDX models.

This study shows that inherent mutation patterns in human genes distinguish cancer genes from non-cancer genes and shape their mutation profiles.

A yeast-based refactoring platform (HEx) with new inducible promoters, an engineered host strain, and homology-based assembly expressed 41 cryptic fungal gene clusters; 22 yielded non-native compounds.