George Chaconas

This study identifies eleven new adhesins in Borrelia burgdorferi that mediate interactions with activated endothelial cells during infection, revealing a dynamic network involved in spirochete transmigration.

This paper shows B. burgdorferi crosses endothelial monolayers via a transcellular pathway requiring Cdc42 for internalization and Rac1 for egress.

The paper introduces MINNO, a tool that refines metabolic networks using empirical metabolomics data, demonstrating its application in studying non-model organisms like Borrelia species.