Theodore B. Verhey

Microbiome-derived hydroxyphenyl propanoates enhance antitumour immunity by potentiating gasdermin D activity in tumour-associated myeloid cells

This study identifies microbiome-derived hydroxyphenyl propanoates (HPPs) that enhance antitumour immunity by boosting gasdermin D activity in myeloid cells, improving immune checkpoint therapy outcomes in mice and correlating with better responses in human melanoma patients.

XenoSignal: Investigating Intra- and Inter-Species Ligand-Receptor Interactions Using AlphaFold3

XenoSignal assesses ligand-receptor interactions across species using AlphaFold3 predictions to improve understanding of tumor-microenvironment crosstalk in xenograft models.

spOT-NMF: Optimal Transport-Based Matrix Factorization for Accurate Deconvolution of Spatial Transcriptomics

spOT-NMF improves spatial transcriptomics deconvolution by using optimal transport, outperforming existing methods in accuracy and scalability across various resolutions and species.

Transendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1

This paper shows B. burgdorferi crosses endothelial monolayers via a transcellular pathway requiring Cdc42 for internalization and Rac1 for egress.

mosaicMPI: a framework for modular data integration across cohorts and -omics modalities

mosaicMPI integrates multi-omics data across cohorts to reveal biological themes and enable rapid mapping of new datasets.