Transendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1
Daiana Alvarez-Olmedo, Claire Kamaliddin, Theodore B. Verhey…·George Chaconas
This paper shows B. burgdorferi crosses endothelial monolayers via a transcellular pathway requiring Cdc42 for internalization and Rac1 for egress.