Targeting GPR183 to reduce peripheral sensitization: evidence from rodent and human tissue analyses
Kyle Oberkrom, Kathryn Braden, Evelyn Li, Samay R. Shah, Dragan Maric, Andrew J. Mannes, Paola Pacifico, Nirupa D. Jayaraj, Christopher Kent Arnatt, Daniela Maria Menichella, Matthew R. Sapio, Daniela Salvemini
This study identifies GPR183 as a driver of peripheral sensitization in rodents and humans, showing its role in pain pathways through immune cell activation and highlighting its potential as a therapeutic target.
bioRxiv · Jan 16, 2026 · PreprintPharmacology & Toxicology