Author

Nirupa D. Jayaraj

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Pharmacology & Toxicology· 1

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Daniela Maria MenichellaiD· 4 shared Dongjun ReniD· 3 shared Paola PacificoiD· 3 shared Richard J. MilleriD· 3 shared Abdelhak A. BelmadaniiD· 2 shared Amy S. PalleriD· 2 shared Dale GeorgeiD· 2 shared James S. Coy-DibleyiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersNeuroscience

Daniela Maria MenichellaORCID

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4 papers

Recent·Most cited

Epidermal Langerhans Cells Drive Painful Diabetic Neuropathy in a Sex-dependent Manner

Paola Pacifico, Dale George, Nirupa D. Jayaraj, Dongjun Ren, James S. Coy-Dibley, Abdelhak A. Belmadani, Sofia Veronesi, Mirna Anđelić, Daniele Cartelli, Grazia Devigili, Raffaella Lombardi, Giuseppe Lauria, Amy S. Paller, Richard J. Miller, Daniela Maria Menichella

This study identifies epidermal Langerhans cells as key contributors to painful diabetic neuropathy, revealing sex-dependent roles in mechanical allodynia and pain behavior.

Journal of Clinical Investigation · Apr 30, 2026Peer-reviewedNeuroscience

Targeting GPR183 to reduce peripheral sensitization: evidence from rodent and human tissue analyses

Kyle Oberkrom, Kathryn Braden, Evelyn Li, Samay R. Shah, Dragan Maric, Andrew J. Mannes, Paola Pacifico, Nirupa D. Jayaraj, Christopher Kent Arnatt, Daniela Maria Menichella, Matthew R. Sapio, Daniela Salvemini

This study identifies GPR183 as a driver of peripheral sensitization in rodents and humans, showing its role in pain pathways through immune cell activation and highlighting its potential as a therapeutic target.

bioRxiv · Jan 16, 2026 · PreprintPharmacology & Toxicology

Keratinocyte-derived exosomes in painful diabetic neuropathy

James S. Coy-Dibley, Nirupa D. Jayaraj, Dongjun Ren, Paola Pacifico, Abdelhak A. Belmadani, Yizhi Wang, Kamil K. Gebis, Jeffrey N. Savas, Amy S. Paller, Richard J. Miller, Daniela Maria Menichella

This study investigates keratinocyte-derived exosomes in a mouse model of painful diabetic neuropathy, finding differences in their molecular content and showing retrograde trafficking to DRG neurons.

bioRxiv · Aug 21, 2024 · PreprintNeuroscience

A subpopulation of peripheral sensory neurons expressing the Mas-related G Protein-Coupled Receptor d (Mrgprd) generates pain hypersensitivity in painful diabetic neuropathy.

Dale George, Nirupa D. Jayaraj, Dongjun Ren, Rachel E. Miller, Anne‐Marie Malfait, Richard J. Miller, Daniela Maria Menichella

The paper identifies Mrgprd-expressing DRG neurons as a driver of pain hypersensitivity in a mouse model of PDN and shows targeting these neurons can reverse mechanical allodynia.

bioRxiv · Oct 27, 2022 · PreprintNeuroscience