Daniela Maria Menichella

This study identifies epidermal Langerhans cells as key contributors to painful diabetic neuropathy, revealing sex-dependent roles in mechanical allodynia and pain behavior.

This study identifies GPR183 as a driver of peripheral sensitization in rodents and humans, showing its role in pain pathways through immune cell activation and highlighting its potential as a therapeutic target.

This study investigates keratinocyte-derived exosomes in a mouse model of painful diabetic neuropathy, finding differences in their molecular content and showing retrograde trafficking to DRG neurons.

The paper identifies Mrgprd-expressing DRG neurons as a driver of pain hypersensitivity in a mouse model of PDN and shows targeting these neurons can reverse mechanical allodynia.